Protein C Inhibitor May Modulate Human Sperm-Oocyte Interactions1
نویسندگان
چکیده
منابع مشابه
The multifaceted C. elegans major sperm protein: an ephrin signaling antagonist in oocyte maturation.
In sexually reproducing animals, the ability to coordinate oocyte maturation and sperm availability has profound effects on reproductive success. InCaenorhabditis elegans, cell–cell signaling is crucial for promoting germline development, oocyte maturation, and ovulation. In this issue of Genes & Development, Miller et al. (2003) provide new insights into the role that sperm play in oocyte matu...
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Innexins are the subunits of invertebrate gap junctions. Here we show that the innexin INX-14 promotes sperm guidance to the fertilization site in the Caenorhabditis elegans hermaphrodite reproductive tract. inx-14 loss causes cell nonautonomous defects in sperm migration velocity and directional velocity. Results from genetic and immunocytochemical analyses provide strong evidence that INX-14 ...
متن کاملOocyte-sperm interactions.
The penetration of the zona pellucida is a crucial step during fertilization. Spermatozoa that are unable to recognize and bind to the zona pellucida glycoproteins or respond to the zona pellucida by undergoing the acrosome reaction fail to fertilize the egg. In most mammalian species, after entering the fallopian tube sperm are stored in the isthmic part of the oviduct under conditions that ma...
متن کاملHuman tMDC III: a sperm protein with a potential role in oocyte recognition.
A number of MDC (metalloproteinase-like, disintegrin-like, cysteine-rich) proteins are exclusively or abundantly expressed on mammalian sperm from a range of species, with data from rodents supporting a role for some of these in oolemma binding. However, in the human, transcripts for three of the most likely candidates have been shown to contain deletions and in-frame termination codons, render...
متن کاملExpression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization.
OBJECTIVE To investigate the expression of oocyte-specific linker histone protein (hH1FOO) in human ovaries and its incorporation into sperm chromatin after intracytoplasmic sperm injection (ICSI). DESIGN Laboratory study. SETTING University hospital. PATIENT(S) Human ovarian tissues were obtained from patients at oophorectomy. Human oocytes and embryos were obtained from infertile patien...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 1998
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod58.3.670